Sam meets and falls in love with a hustler and former prostitute, Ginger McKenna ( Sharon Stone). Nicky's volatile temper soon gets him banned from every casino in Las Vegas, so he gathers his own crew and engages in independent shakedowns and burglaries instead. Impressed with his work, mafia boss Remo Gaggi ( Pasquale Cajano) sends Sam's childhood friend and mob enforcer Nicholas 'Nicky' Santoro ( Joe Pesci) and his associate Frank 'Frankie' Marino ( Frank Vincent) to protect Sam and the whole operation. Taking advantage of gaming laws that allow him to work in a casino while his gaming license is pending, Sam doubles the casino's profits, which are skimmed by the mafia before they are reported to income tax agencies. In 1973, sports handicapper and mafia associate Sam 'Ace' Rothstein ( Robert De Niro) is sent to Las Vegas to run the Teamsters Union-funded Tangiers Casino on behalf of the Chicago Outfit, which secretly controls the Teamsters, while Philip Green ( Kevin Pollack) serves as the mob's frontman.

At first, he's a great success in the job, but over the years, problems with his loose-cannon enforcer Nicky Santoro ( Joe Pesci), his ex-hustler wife Ginger ( Sharon Stone), her con-artist ex Lester Diamond ( James Woods) and a handful of corrupt politicians put Sam in ever-increasing danger. In the early-1970s Las Vegas, low-level mobster Sam 'Ace' Rothstein ( Robert De Niro) gets tapped by his bosses to head the Tangiers Casino. The film is based on the non-fiction book Casino: Love and Honor in Las Vegas by Nicholas Pileggi, who also co-wrote the screenplay for the film with Scorsese.

This marks the eighth collaboration of Scorsese and De Niro, with the two previously collaborating on the another hit mafia film Goodfellas (1990). Casino is a 1995 American epic crime] drama film directed by Martin Scorsese and starring Robert De Niro, Joe Pesci, Sharon Stone, Don Rickles, Kevin Pollak and James Woods.

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